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RNA sequencing can capture high-resolution snapshots of a cell’s transcriptome, but transient changes in individual cells cannot be captured over long periods at a transcriptome-wide scale. Now, a synthetic organelle termed the ‘recordanelle’ can record cellular RNAs in cells for several days and be read with single-cell sensitivity.
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References
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Askary, A. et al. The lives of cells, recorded. Nat. Rev. Genet. 26, 203–222 (2025). This review discusses DNA-based recording technologies.
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Schmidt, F., Cherepkova, M. Y. & Platt, R. J. Transcriptional recording by CRISPR spacer acquisition from RNA. Nature 562, 380–385 (2018). This paper established CRISPR-based RNA recording in prokaryotic cells.
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This is a summary of: Reinkemeier, C. D. et al. Recordanelles for transcriptome-wide single-cell RNA recording in human cells. Nat. Biotechnol. https://doi.org/10.1038/s41587-026-03327-6 (2026).
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Recordanelles capture transient gene expression in single human cells. Nat Biotechnol (2026). https://doi.org/10.1038/s41587-026-03350-7
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DOI: https://doi.org/10.1038/s41587-026-03350-7
